Description

10-Acetyl-5,8-Dideazafolic Acid is a key synthetic intermediate in the development of novel chemotherapeutic agents and enzyme inhibitors. This compound is of significant value in pharmaceutical research for its role as a precursor in the synthesis of more complex antifolate molecules. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology drug discovery and biochemical pathway studies.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced antifolate compounds and thymidylate synthase inhibitors for cancer research.
• Biochemical Research: Used as a reference standard and building block in studies of folate metabolism and enzyme kinetics.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Academic Research: Employed in university and institutional labs for investigating nucleotide biosynthesis and targeted cancer therapies.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing of specialized, high-value chemical entities.

Basic Information

Product Name	10-Acetyl-5,8-Dideazafolic Acid
CAS No.	94843-77-3
Molecular Formula	C21H21N5O6
Molecular Weight	439.43 g/mol
Synonyms	10-Acetyl-5,8-dideazafolic acid; 10-Acetyl-DDATHF; 10-Acetyl-5,8-dideazapteroylglutamic acid; 10-Acetyl-Lometrexol intermediate; N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-quinazolinyl)methyl]amino]benzoyl]-L-glutamic acid 10-acetate; 5,8-Dideaza-10-acetylfolic acid; Acetyl-DDATHF; L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-quinazolinyl)methyl]amino]benzoyl]-, 10-acetate
EINECS	Contact for details

Quality Control

Our 10-Acetyl-5,8-Dideazafolic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.