Description

4-Hydroxy Propranolol Glucuronide is a major, pharmacologically relevant metabolite of the widely used β-blocker propranolol. This compound is critical for research and development in pharmaceutical analysis and drug metabolism studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, pharmacokinetic profiling, and metabolite identification.

Application

• Reference Standard for Bioanalysis: Serves as a certified reference material (CRM) for the quantification of propranolol metabolites in biological matrices (plasma, urine) using LC-MS/MS or HPLC.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and pharmacokinetic behavior of propranolol in preclinical and clinical research.
• Pharmaceutical Impurity Profiling: Used as an impurity standard to monitor and control the levels of specific metabolites during drug substance and drug product stability testing.
• Enzyme Activity Assays: Employed in vitro studies to assess the activity of UDP-glucuronosyltransferase (UGT) enzymes responsible for the glucuronidation metabolic pathway.
• Toxicological Research: Aids in understanding the safety profile and potential toxicological implications of propranolol's metabolic products.
• Clinical Research Support: Provides a definitive standard for correlating metabolite levels with drug efficacy or side effects in patient studies.

Basic Information

Item	Details
Product Name	4-Hydroxy Propranolol Glucuronide
CAS No.	94731-13-2
Molecular Formula	C22H33NO9
Molecular Weight	455.50 g/mol
Synonyms	1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol 4-Glucuronide; Propranolol 4-O-Glucuronide; 4'-Hydroxypropranolol Glucuronide; 4-Hydroxypropranolol β-D-Glucopyranosiduronic Acid; 4-OH-Propranolol Glucuronide; Propranolol Metabolite 4-Glucuronide; 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol 4-β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Propranolol Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and analytical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.