Description

Suc-Leu-Leu-Val-Tyr-Amc CAS NO 94367-21-2 is a fluorogenic peptide substrate designed for the sensitive and continuous assay of proteolytic enzyme activity. This compound is a critical tool in biochemical research, enabling the study of protease kinetics, inhibitor screening, and enzyme characterization. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors for drug discovery and diagnostic development.

Application

• Protease Activity Assays: A standard fluorogenic substrate for chymotrypsin-like proteases, including the 20S proteasome.
• Drug Discovery & Screening: High-throughput screening (HTS) of potential protease inhibitors for therapeutic development.
• Enzyme Kinetics Studies: Determination of kinetic parameters (Km, Vmax, kcat) for proteolytic enzymes.
• Biochemical Research: Investigation of proteasome function, protein degradation pathways, and cellular regulation.
• Diagnostic Development: Component in assay kits for measuring proteasome activity in clinical and research samples.
• Quality Control: Used in QC labs to validate the activity and specificity of enzyme preparations.

Basic Information

Product Name	Suc-Leu-Leu-Val-Tyr-Amc
CAS No.	94367-21-2
Molecular Formula	C34H53N5O9
Molecular Weight	675.82 g/mol
Synonyms	Suc-LLVY-AMC; Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin; N-Succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin; Proteasome Substrate Suc-LLVY-AMC; Chymotrypsin Substrate; Fluorogenic Proteasome Substrate; 20S Proteasome Substrate; N-Succinyl-L-leucyl-L-leucyl-L-valyl-L-tyrosine 7-amido-4-methylcoumarin
EINECS	Contact for details

Quality Control

Our Suc-Leu-Leu-Val-Tyr-Amc is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive assays. Each lot is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay results, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.