Description

6(S)-Lipoxin A4 is a specialized, stereochemically defined lipoxin, a class of potent bioactive lipid mediators derived from arachidonic acid. This compound is critical for research into the endogenous resolution of inflammation, offering a pathway to develop novel therapeutic strategies for chronic inflammatory diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers in immunology and biochemistry, and biotechnology companies focused on inflammation and resolution pharmacology.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating the molecular mechanisms of inflammation resolution.
• Drug Discovery & Development: Serves as a lead compound or pharmacological tool for developing new anti-inflammatory and pro-resolving therapeutics.
• Cell Signaling Studies: Applied in vitro and in vivo to study specific receptor interactions (e.g., ALX/FPR2) and downstream signaling pathways.
• Analytical Standard: Essential for the calibration of analytical equipment (HPLC, LC-MS) in bioanalytical method development for lipidomics.
• Preclinical Models: Used in animal models of disease to evaluate the efficacy of resolution agonists in conditions like colitis, arthritis, and asthma.

Basic Information

Product Name	6(S)-Lipoxin A4
CAS No.	94292-80-5
Molecular Formula	C20H32O5
Molecular Weight	352.47 g/mol
Synonyms	Lipoxin A4; LXA4; (5S,6R,15S)-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic Acid; 6S-Lipoxin A4; 5S,6R,15S-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic Acid
EINECS	Contact for details

Quality Control

Our 6(S)-Lipoxin A4 is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and stability data.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is hygroscopic and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95% (Area Percent)
Stereochemical Purity	≥ 98% (6S-isomer)
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.