Description

Glycerophosphoinositol 4,5-Bisphosphate is a high-purity, biologically significant phospholipid derivative. This compound is a critical intermediate and signaling molecule in cellular biochemical pathways, particularly those involving phosphoinositide metabolism. It is essential for research and development in life sciences, serving as a key reagent for studying intracellular signal transduction, membrane dynamics, and enzyme kinetics. This product is primarily targeted at pharmaceutical R&D, academic biochemistry research, and diagnostic assay development.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic assays to study phosphatidylinositol-specific phospholipase C (PI-PLC) and other phosphoinositide-metabolizing enzymes.
• Cell Signaling Studies: Serves as a critical precursor or analog in investigating the phosphoinositide pathway, which regulates processes like cell growth, proliferation, and differentiation.
• Pharmaceutical Development: Employed in drug discovery programs targeting lipid kinases, phosphatases, and phospholipases for therapeutic interventions in cancer and metabolic diseases.
• Diagnostic Reagent Manufacturing: Utilized as a key component in the development of in vitro diagnostic (IVD) kits for research purposes, particularly those measuring enzyme activity or lipid metabolites.
• Membrane Biophysics: Acts as a model compound for studying the biophysical properties and organization of phosphoinositides within lipid bilayers and membranes.

Basic Information

Product Name	Glycerophosphoinositol 4,5-Bisphosphate
CAS No.	94161-15-6
Molecular Formula	C9H20O18P3
Molecular Weight	548.13 g/mol
Synonyms	GPI(4,5)P2; Glycerophospho-myo-inositol 4,5-bisphosphate; 1-(1,2-Di-O-palmitoyl-rac-glycero-3-phospho)-1D-myo-inositol 4,5-bisphosphate; D-myo-Inositol 1,2-cyclic phosphate 4,5-bisphosphate; Phosphatidylinositol 4,5-bisphosphate analog; PtdIns(4,5)P2 derivative; Inositol phospholipid intermediate; GPI-anchor pathway metabolite
EINECS	Contact for details

Quality Control

Our Glycerophosphoinositol 4,5-Bisphosphate is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized using advanced analytical techniques including NMR and mass spectrometry to confirm identity and structure. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in chloroform/methanol mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.