Description

n-[(Benzyloxy)Carbonyl]-L-Alanine Succinic Anhydride is a key chiral building block and activated ester derivative used in peptide synthesis and pharmaceutical intermediate manufacturing. This compound is specifically designed for the controlled introduction of the N-protected L-alanine moiety, offering high reactivity and stereochemical integrity. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: As an activated ester for the efficient, racemization-free coupling of Cbz-L-Alanine in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: A critical precursor in the multi-step synthesis of complex drug molecules, particularly peptide hormones and enzyme inhibitors.
• Bioconjugation: Used to modify proteins, antibodies, or other biomolecules by introducing specific functional handles or protected amino acid linkages.
• Protecting Group Chemistry: Serves as a reagent for introducing the benzyloxycarbonyl (Cbz) protecting group onto amino functionalities in complex molecular architectures.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for drug discovery and high-throughput screening campaigns.
• Academic & Industrial Research: A valuable tool for synthetic organic chemists exploring new methodologies in amide bond formation and asymmetric synthesis.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-L-Alanine Succinic Anhydride
CAS No.	93964-71-7
Molecular Formula	C15H15NO6
Molecular Weight	305.28 g/mol
Synonyms	Cbz-L-Alanine Succinimidyl Ester; N-Cbz-L-Alanine N-Hydroxysuccinimide Ester; N-(Benzyloxycarbonyl)-L-alanine N-succinimidyl ester; NSC 334368; (S)-2-(((Benzyloxy)carbonyl)amino)propanoic acid 2,5-dioxopyrrolidin-1-yl ester; N-Succinimidyl N-Cbz-L-alaninate; N-Cbz-L-Ala-OSu; Z-L-Ala-OSu
EINECS	Contact for details

Quality Control

Our n-[(Benzyloxy)Carbonyl]-L-Alanine Succinic Anhydride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.