Description

Rebeccamycin is a potent indolocarbazole antibiotic and topoisomerase I inhibitor originally isolated from the actinomycete Lechevalieria aerocolonigenes. This compound matters significantly for its role as a critical pharmaceutical intermediate in the development of novel anticancer agents and as a valuable tool in biochemical research. It is primarily needed by pharmaceutical R&D laboratories, biotech companies developing targeted therapies, and academic institutions conducting cancer biology studies.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or precursor in the synthesis of more potent, clinically evaluated anticancer analogs and derivatives.
• Biochemical Research: Used as a specific inhibitor of DNA topoisomerase I in mechanistic studies of DNA replication, transcription, and repair.
• Anticancer Agent Development: Provides the core indolocarbazole structure for structure-activity relationship (SAR) studies aimed at improving efficacy and reducing toxicity.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for pharmaceutical manufacturing.
• Microbiology Research: Studied for its antibiotic properties and mechanism of action against various bacterial strains.

Basic Information

Item	Details
Product Name	Rebeccamycin
CAS No.	93908-02-2
Molecular Formula	C₃₁H₂₃ClN₂O₈
Molecular Weight	586.97 g/mol
Synonyms	NSC 655649; Antibiotic LL-D49194; Rebeccamycin, 7-Chloro-9-methoxy-2,5,12,16,18,21-hexahydroxy-23-methyl-20,25-dioxo-7,12-epoxy-7H-pyrido[4,3-c]carbazole-4-carbonitrile; LL-D49194; Rebeccamycin (Antibiotic); 7-Chloro-9-methoxy-2,5,12,16,18,21-hexahydroxy-23-methyl-20,25-dioxo-7,12-epoxy-7H-pyrido[4,3-c]carbazole-4-carbonitrile
EINECS	Contact for details

Quality Control

Our Rebeccamycin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange-brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.