Description

8-(4-Chlorophenylthio)-Adenosine 3':5'-Cyclic Monophosphate Sodium Salt is a chemically modified, cell-permeable analog of cyclic adenosine monophosphate (cAMP), a fundamental secondary messenger in cellular signal transduction. This compound is specifically engineered to activate protein kinase A (PKA) with high potency and stability, making it an invaluable tool for modulating intracellular signaling pathways in research. It is primarily utilized by researchers and developers in the fields of biochemistry, molecular biology, and pharmacology for studying cellular processes, drug discovery, and metabolic regulation.

Application

• Biochemical Research: As a potent and stable activator of Protein Kinase A (PKA) for investigating cAMP-mediated signaling pathways in cell cultures and enzymatic assays.
• Pharmaceutical R&D: Used as a reference standard and a key pharmacological tool compound in drug discovery programs targeting G-protein-coupled receptors (GPCRs) and intracellular signaling.
• Cell Biology Studies: For probing the role of cAMP in cellular functions such as gene expression, metabolism, ion channel regulation, and cell differentiation.
• Metabolic Research: Investigation of hormonal regulation, including glucagon and epinephrine signaling, in metabolic tissues like liver and adipose tissue.
• Neuroscience Research: Studying synaptic plasticity, neurotransmitter release, and neuronal excitability modulated by PKA.
• Academic & Institutional Laboratories: A critical reagent for basic scientific research and teaching in graduate-level cell signaling courses.

Basic Information

Product Name	8-(4-Chlorophenylthio)-Adenosine 3':5'-Cyclic Monophosphate Sodium Salt
CAS No.	93882-12-3
Molecular Formula	C17H16ClN5NaO6PS
Molecular Weight	515.82 g/mol
Synonyms	8-CPT-cAMP Sodium Salt; 8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphate sodium salt; 8-CPT-cyclic AMP sodium salt; 8-(p-Chlorophenylthio)-cAMP sodium salt; 8-(4-Chlorophenylthio)-cAMP Na salt; Rp-8-CPT-cAMPS sodium salt (less common isomer); Adenosine 3',5'-cyclic monophosphate, 8-(4-chlorophenylthio)-, sodium salt; cAMP analog, cell-permeable.
EINECS	Contact for details

Quality Control

Our 8-(4-Chlorophenylthio)-Adenosine 3':5'-Cyclic Monophosphate Sodium Salt is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.