Description

Adenosine 5'-[γ-Thio]Triphosphate Tetralithium Salt is a chemically modified, non-hydrolyzable analog of adenosine triphosphate (ATP) where a sulfur atom replaces an oxygen atom in the gamma phosphate group. This compound is critically important as a potent and selective inhibitor of ATP-dependent enzymes, making it an indispensable tool for mechanistic studies in biochemistry and molecular biology. It is primarily needed by researchers in pharmaceutical development, academic institutions, and diagnostic kit manufacturers for kinase assays, phosphorylation studies, and probing enzyme active sites. CAS No. 93839-89-5.

Application

• Biochemical Research & Enzyme Kinetics: Used as a substrate analog to study ATPase and kinase mechanisms, providing insights into enzyme inhibition and catalytic pathways.
• Pharmaceutical Screening Assays: Essential in high-throughput screening (HTS) platforms to identify and characterize potential kinase inhibitors for drug discovery.
• Molecular Biology Reagents: A key component in kits for studying protein phosphorylation, signal transduction pathways, and nucleic acid metabolism.
• Diagnostic Development: Employed in the formulation of diagnostic assays that monitor enzymatic activity related to various diseases.
• Structural Biology: Used in X-ray crystallography and other structural studies to trap and visualize enzyme-substrate complexes.
• Cell Signaling Studies: Applied in cellular assays to investigate the role of ATP-dependent processes in cell cycle regulation and apoptosis.

Basic Information

Product Name	Adenosine 5'-[γ-Thio]Triphosphate Tetralithium Salt
CAS No.	93839-89-5
Molecular Formula	C10H12Li4N5O12P3S
Molecular Weight	551.04 g/mol
Synonyms	Adenosine 5'-(γ-thiotriphosphate) tetralithium salt; ATPγS tetralithium salt; Adenosine-5'-[γ-thio]-triphosphate tetralithium; γ-Thio-ATP tetralithium salt; Adenosine 5'-(3-thiotriphosphate) tetralithium salt; Li4ATPγS; 2'(3')-O-(2,4,6-Trinitrophenyl)adenosine 5'-triphosphate tetralithium salt analog
EINECS	Contact for details

Quality Control

Our Adenosine 5'-[γ-Thio]Triphosphate Tetralithium Salt is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Quality assurance includes rigorous analytical testing via HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Biological Activity	Tested in standard kinase inhibition assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.