Description

4-Amino-2,2,6,6-Tetramethylpiperidin-1-Oxy-Ouabain is a specialized synthetic intermediate that combines a stable nitroxide radical (TEMPO derivative) with the ouabain pharmacophore. This compound is significant for its role in advanced research, particularly in the study of sodium-potassium ATPase (Na+/K+-ATPase) inhibitors and as a spin label in biophysical chemistry. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on developing novel cardiac therapeutics or advanced spectroscopic probes.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of novel ouabain analogs for investigating cardiac glycoside activity and Na+/K+-ATPase inhibition mechanisms.
• Biophysical Probes: Utilized as a spin label in Electron Paramagnetic Resonance (EPR) spectroscopy for studying protein dynamics, membrane interactions, and conformational changes.
• Chemical Biology Tool: Serves as a molecular probe to explore ion transport and signal transduction pathways in cellular models.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• Specialty Synthesis: Used in the preparation of other nitroxide-labeled bioactive molecules for various research applications.

Basic Information

Product Name	4-Amino-2,2,6,6-Tetramethylpiperidin-1-Oxy-Ouabain
CAS No.	93801-58-2
Molecular Formula	C35H55N3O9
Molecular Weight	661.83 g/mol
Synonyms	Ouabain TEMPO Amine; 4-Amino-TEMPO-Ouabain; 1-Oxy-4-amino-2,2,6,6-tetramethylpiperidine ouabain conjugate; 4-AT-Ouabain; Strophanthin G TEMPO derivative; G-Strophanthin spin label; CAS 93801-58-2
EINECS	Contact for details

Quality Control

Our 4-Amino-2,2,6,6-Tetramethylpiperidin-1-Oxy-Ouabain is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.