Description

4Alpha-Phorbol 12,13-Dibutyrate is a potent, cell-permeable diacylglycerol (DAG) analog and a protein kinase C (PKC) activator widely used in biochemical and pharmacological research. This compound is critical for studying signal transduction pathways, cellular proliferation, and tumor promotion mechanisms. It is an essential tool for researchers and scientists in the fields of oncology, immunology, and molecular biology.

Application

• Biochemical Research: As a potent activator of Protein Kinase C (PKC) isoforms, used to study intracellular signaling cascades, cell differentiation, and apoptosis.
• Oncology Studies: Employed in cancer research to investigate tumor promotion mechanisms and the role of PKC in carcinogenesis and metastasis.
• Immunology Research: Used to examine PKC-mediated activation pathways in immune cells, including T-cells and macrophages.
• Neuroscience: Applied in studies of neurotransmitter release, synaptic plasticity, and neuronal survival where PKC signaling is involved.
• Pharmacological Screening: Serves as a reference standard and tool compound in high-throughput screening for novel PKC inhibitors and modulators.
• Cell Culture & In Vitro Assays: Used to stimulate specific cellular responses in controlled laboratory environments to model disease states.

Basic Information

Product Name	4Alpha-Phorbol 12,13-Dibutyrate
CAS No.	93781-54-5
Molecular Formula	C36H56O8
Molecular Weight	616.83 g/mol
Synonyms	Phorbol 12,13-Dibutyrate; PDBu; 4α-Phorbol 12,13-Dibutyrate; 4-α-Phorbol-12,13-dibutyrate; NSC 293447; 12,13-Dibutyrate 4alpha-phorbol; Phorbol-12,13-dibutyric acid ester; TPA analog
EINECS	Contact for details

Quality Control

Every batch of 4Alpha-Phorbol 12,13-Dibutyrate is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and batch-to-batch consistency suitable for sensitive research applications. A detailed Certificate of Analysis (COA) providing purity, identity confirmation, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.