Description

8-Azidoguanosine-3',5'-Diphosphate CAS NO 93590-12-6 is a chemically modified nucleotide analog featuring an azido group, making it a valuable photoaffinity labeling and crosslinking reagent. This compound is critical for biochemical research, enabling the study of nucleotide-binding proteins and enzymatic mechanisms. It is primarily utilized by research institutions and pharmaceutical companies engaged in molecular biology, enzymology, and drug discovery.

Application

• Photoaffinity Labeling: Acts as a key reagent for covalently tagging and identifying nucleotide-binding sites on proteins and enzymes upon UV irradiation.
• Enzyme Mechanism Studies: Used to probe the active sites and catalytic mechanisms of kinases, polymerases, and other nucleotide-dependent enzymes.
• Crosslinking Agent: Facilitates the study of protein-protein and protein-nucleic acid interactions through azide-based crosslinking chemistry.
• Bioconjugation: Serves as a versatile building block for "click chemistry" applications, allowing for the site-specific attachment of probes, tags, or other molecules.
• Structural Biology: Aids in the structural analysis of macromolecular complexes by providing a means to trap transient interactions.
• Drug Discovery Screening: Employed in high-throughput assays to identify and characterize inhibitors of nucleotide-binding targets.

Basic Information

Product Name	8-Azidoguanosine-3',5'-Diphosphate
CAS No.	93590-12-6
Molecular Formula	C10H13N8O13P2
Molecular Weight	515.20 g/mol
Synonyms	8-N3-GDP; 8-Azido-GDP; Guanosine 3',5'-diphosphate, 8-azido-; 8-Azidoguanosine diphosphate; 8-Azido-3',5'-GDP; 8-Azido-GDP, sodium salt (common form); 8-Azidoguanosine-3',5'-pyrophosphate
EINECS	Contact for details

Quality Control

Our 8-Azidoguanosine-3',5'-Diphosphate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals, ensuring reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment to maintain stability, as the compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.