Description

2'-Deoxy-3'-Ketouridine 5'-Diphosphate is a chemically modified nucleotide derivative of significant interest in advanced biochemical research and development. This compound serves as a critical building block and a key intermediate in the synthesis of novel nucleoside analogs and modified oligonucleotides. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for antiviral and anticancer therapeutic programs, as well as in the study of enzyme mechanisms and nucleic acid chemistry.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving polymerases, kinases, and other nucleic acid-metabolizing enzymes.
• Probe Development: Acts as a modified building block for creating labeled or cross-linking probes to study nucleic acid structure and function.
• Mechanistic Studies: Essential tool for investigating reaction pathways and catalytic mechanisms in nucleotide chemistry.
• Oligonucleotide Synthesis: Specialized monomer for incorporating unique modifications into synthetic DNA/RNA strands for diagnostic or therapeutic applications.

Basic Information

Product Name	2'-Deoxy-3'-Ketouridine 5'-Diphosphate
CAS No.	92544-21-3
Molecular Formula	C9H13N2O13P2
Molecular Weight	434.15 g/mol
Synonyms	3'-Keto-2'-deoxyuridine 5'-diphosphate; dUDP-3'-one; 2'-Deoxy-3'-oxouridine 5'-diphosphate; 3'-Oxo-2'-deoxyuridine diphosphate; 5'-dUDP-3'-one; 3'-Ketodeoxyuridine diphosphate; Uridine, 2'-deoxy-3'-oxo-, 5'-(trihydrogen diphosphate)
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-3'-Ketouridine 5'-Diphosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 90% (anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.