Description

o-((n-Succinimidyl)Succinyl-Aminoethyl)& CAS NO 92451-00-8 is a specialized heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a carboxyl group. This compound is critical for creating stable amide bonds between biomolecules, enabling precise conjugation in complex biochemical systems. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and the production of diagnostic reagents and targeted therapeutics.

Application

• Bioconjugation reagent for linking proteins, peptides, and antibodies to other molecules (e.g., drugs, dyes, polymers).
• Key intermediate in the synthesis of Antibody-Drug Conjugates (ADCs) for targeted cancer therapy.
• Surface functionalization and immobilization of biomolecules on solid supports for biosensor and microarray development.
• Crosslinking agent in the preparation of immunogens for antibody production.
• Tool compound in proteomics research for studying protein-protein interactions and protein labeling.
• Modification of nanoparticles and drug delivery carriers for active targeting applications.

Basic Information

Product Name	o-((n-Succinimidyl)Succinyl-Aminoethyl)& CAS NO 92451-00-8
CAS No.	92451-00-8
Molecular Formula	C12H16N2O7
Molecular Weight	300.27 g/mol
Synonyms	N-Succinimidyl 3-[(2-aminoethyl)amino]-3-oxopropanoate; 3-[(2-Aminoethyl)amino]-3-oxopropanoic Acid N-Hydroxysuccinimide Ester; 2,5-Dioxopyrrolidin-1-yl 3-[(2-aminoethyl)carbamoyl]propanoate; N-(2-Aminoethyl)succinamic Acid N-Hydroxysuccinimide Ester; Succinimidyl Succinylaminoethyl Ester; NHS-SAE; SAE-NHS; o-(N-Succinimidyl)succinylaminoethyl Ester
EINECS	Contact for details

Quality Control

Our o-((n-Succinimidyl)Succinyl-Aminoethyl)& CAS NO 92451-00-8 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and biopharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.