Description

4,5-Dimethoxy-2-Nitrobenzyl Cyclic Gmp is a specialized caged compound used as a photolabile protecting group for biologically active molecules. This compound matters for researchers and manufacturers requiring precise, light-triggered release of cyclic guanosine monophosphate (cGMP) or other functional groups in controlled environments. It is primarily needed by the pharmaceutical, biotechnology, and life science research sectors for applications in photopharmacology, neuroscience, and cellular signaling studies.

Application

• Photopharmacology Research: As a key reagent for the light-activated release of cGMP to study intracellular signaling pathways.
• Neuroscience Studies: Enables precise temporal and spatial control over cGMP concentration in neurons and other cell types.
• Caged Compound Synthesis: Serves as a photolabile precursor for synthesizing other caged nucleotides and signaling molecules.
• Cellular Biology Assays: Used in experiments investigating the role of cGMP in processes like vision, smooth muscle relaxation, and platelet aggregation.
• Drug Discovery Platforms: Facilitates the development of light-activated prodrugs and tools for target validation.
• Biochemical Reagent Manufacturing: A critical intermediate for producing high-purity research chemicals and assay kits.

Basic Information

Product Name	4,5-Dimethoxy-2-Nitrobenzyl Cyclic Gmp
CAS No.	92313-26-3
Molecular Formula	C₁₉H₂₀N₆O₁₀P
Molecular Weight	532.37 g/mol
Synonyms	4,5-Dimethoxy-2-nitrobenzyl cGMP; cGMP, 4,5-dimethoxy-2-nitrobenzyl ester; DMNB-cGMP; 2-Nitro-4,5-dimethoxybenzyl cyclic GMP; NPE-cGMP analog; Photolabile caged cGMP; 1-(4,5-Dimethoxy-2-nitrophenyl)ethyl cGMP; Cyclic 3',5'-guanosine monophosphate, 4,5-dimethoxy-2-nitrobenzyl ester
EINECS	Contact for details

Quality Control

Our 4,5-Dimethoxy-2-Nitrobenzyl Cyclic Gmp is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. Due to its hygroscopic and strictly light-sensitive nature, the material should be handled under inert atmosphere or low-light conditions when aliquoting for use. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.