Description

D-Myo-Inositol 2,4,5-Trisphosphate, Hexaammonium Salt is a high-purity, cell-permeant derivative of inositol trisphosphate (IP3), a critical second messenger in cellular signal transduction. This compound is essential for researchers studying intracellular calcium release, phosphoinositide metabolism, and related signaling pathways in physiology and pharmacology. It is primarily utilized by biotech and pharmaceutical R&D teams, as well as academic institutions, for advanced biochemical and cell biology research.

Application

• Biochemical Research: A key tool for investigating the IP3 receptor-mediated calcium signaling cascade in cell-free systems and permeabilized cells.
• Cell Biology Studies: Used to induce controlled intracellular calcium release to study its effects on processes like muscle contraction, neurotransmitter release, and gene expression.
• Drug Discovery & Pharmacology: Serves as a reference standard and agonist in high-throughput screening assays to identify novel modulators of the IP3 receptor for therapeutic development.
• Neuroscience Research: Applied to study the role of calcium signaling in neuronal function, synaptic plasticity, and neurodegenerative disease models.
• Cardiovascular Research: Utilized to examine calcium-induced calcium release mechanisms in cardiac and smooth muscle cells.
• Enzymology: Acts as a substrate for studying the activity and kinetics of inositol polyphosphate kinases and phosphatases.

Basic Information

Product Name	D-Myo-Inositol 2,4,5-Trisphosphate, Hexaammonium Salt
CAS No.	92216-45-0
Molecular Formula	C6H6O15P3 · 6NH3
Molecular Weight	681.19 g/mol (as hexaammonium salt)
Synonyms	Ins(2,4,5)P3 Hexaammonium Salt; D-myo-Inositol 2,4,5-trisphosphate hexaammonium salt; IP3 Hexaammonium Salt; Inositol 2,4,5-trisphosphate; 1D-myo-Inositol 2,4,5-trisphosphate; 2,4,5-IP3; D-Ins(2,4,5)P3; myo-Inositol 2,4,5-trisphosphate ammonium salt
EINECS	Contact for details

Quality Control

Our D-Myo-Inositol 2,4,5-Trisphosphate, Hexaammonium Salt is manufactured under strict quality protocols suitable for research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistent performance and reliability. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Ammonium Content	Conforms to theoretical value
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.