Description

Rac-cis-n-Desmethyl Sertraline Hydrochloride is a key chiral intermediate and a primary metabolite in the synthesis and metabolism of the widely prescribed SSRI antidepressant, sertraline. Its high purity is critical for ensuring the quality, efficacy, and safety of the final active pharmaceutical ingredient (API). This compound is essential for pharmaceutical R&D, analytical reference standard preparation, and process chemistry in the development and manufacturing of neuropsychiatric therapeutics.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of Sertraline Hydrochloride API.
• Metabolite Reference Standard: Critical for bioanalytical method development and validation in pharmacokinetic and toxicology studies.
• Process Chemistry & Impurity Profiling: Used to study synthesis pathways, optimize processes, and identify/control related substances.
• Analytical Research: Serves as a certified reference material (CRM) for HPLC, LC-MS, and other chromatographic assays.
• Regulatory Compliance: Supports regulatory filings (e.g., FDA, EMA) by providing impurity and degradation product characterization.

Basic Information

Product Name	Rac-cis-n-Desmethyl Sertraline Hydrochloride
CAS No.	91797-57-8
Molecular Formula	C16H15Cl2N•HCl
Molecular Weight	337.66 g/mol
Synonyms	(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine Hydrochloride; Desmethylsertraline HCl; n-Desmethyl Sertraline HCl; Sertraline N-Desmethyl Metabolite; cis-N-Desmethylsertraline Hydrochloride; rac-cis-N-Desmethyl Sertraline HCl; UNII-8V71L1X0S5
EINECS	Contact for details

Quality Control

Our Rac-cis-n-Desmethyl Sertraline Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by IR and NMR, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (cis-isomer)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.