Description

n-Succinimidyl 3-Iodobenzoate is a highly reactive and versatile chemical intermediate, primarily used as an amine-reactive crosslinking agent for bioconjugation. Its core value lies in enabling the stable attachment of molecules, such as peptides, proteins, or labels, to various surfaces or other biomolecules for research and diagnostic applications. This compound is essential for scientists and manufacturers in the fields of biotechnology, pharmaceuticals, and diagnostic assay development who require precise and reliable conjugation chemistry.

Application

• Bioconjugation Reagent: For covalently linking amines on proteins, antibodies, or peptides to other functional molecules or solid supports.
• Diagnostic Kit Manufacturing: Used in the development of immunoassays (e.g., ELISA) and biosensors by immobilizing capture antibodies or antigens.
• Affinity Chromatography Ligand Synthesis: Facilitating the creation of custom resins for protein purification.
• Drug Delivery System Development: Conjugating therapeutic agents to targeting moieties like antibodies (Antibody-Drug Conjugates research).
• Fluorescent Probe and Dye Labeling: Attaching fluorophores or other reporter molecules to biomolecules for imaging and detection.
• Surface Functionalization: Modifying nanoparticles, microplates, or chips with amine-reactive groups for subsequent biomolecule attachment.
• Peptide Synthesis and Modification: Serving as a building block or modifying agent in solid-phase peptide synthesis (SPPS).
• Materials Science Research: Creating functionalized polymers or hydrogels with bioactive properties.

Basic Information

Product Name	n-Succinimidyl 3-Iodobenzoate
CAS No.	91487-18-2
Molecular Formula	C11H8INO4
Molecular Weight	345.09 g/mol
Synonyms	3-Iodo-N-succinimidobenzoate; 3-Iodobenzoic Acid N-Hydroxysuccinimide Ester; NHS Ester of 3-Iodobenzoic Acid; 3-Iodobenzoic Acid Succinimidyl Ester; 3-Iodobenzoyloxy Succinimide; SIB; 3-Iodo-Bz-OSu; N-(3-Iodobenzoyloxy)succinimide
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 3-Iodobenzoate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive bioconjugation applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific research or GMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.