Description

Diethylenetriamine n-Hydroxysuccinimide Pentaester is a specialized, multi-functional chemical intermediate designed for advanced conjugation and cross-linking applications. This compound matters for its high reactivity and ability to introduce multiple active succinimide ester groups onto a single diethylenetriamine backbone, enabling efficient and stable bond formation with amine-containing molecules. It is primarily needed by researchers and manufacturers in the bioconjugation, diagnostics, and pharmaceutical development sectors for creating sophisticated probes, drug conjugates, and biomaterials.

Application

• Bioconjugation Reagent: For the covalent attachment of proteins, peptides, antibodies, or enzymes to other biomolecules, nanoparticles, or solid surfaces.
• Cross-linking Agent: Used to create stable cross-links between amine-containing polymers or biomacromolecules for hydrogel formation or material stabilization.
• Diagnostic Kit Component: Employed in the development of immunoassays and biosensors for labeling detection antibodies or capture molecules.
• Drug Delivery System Synthesis: Facilitates the construction of antibody-drug conjugates (ADCs) or polymer-drug conjugates by linking therapeutic payloads to targeting moieties.
• Surface Functionalization: Modifies the surface of magnetic beads, chromatography resins, or other matrices to introduce reactive groups for further coupling.
• Research & Development: Serves as a key intermediate in organic synthesis and chemical biology research for exploring novel conjugation strategies.

Basic Information

Product Name	Diethylenetriamine n-Hydroxysuccinimide Pentaester
CAS No.	91453-10-0
Molecular Formula	C25H31N5O15
Molecular Weight	641.54 g/mol
Synonyms	Diethylenetriamine Penta(succinimidyl glutarate); DTPA-Penta(NHS); NHS-Pentaester of Diethylenetriaminepentaacetic Acid; DTPA Penta(N-hydroxysuccinimide ester); N1,N4,N7-Tris[2-[2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-N1,N4,N7-tris(2-oxoethyl)diethylenetriamine; Penta(succinimidyl) DTPA ester; DTPA-bis(NHS)-Tris(NHS) ester
EINECS	Contact for details

Quality Control

Our Diethylenetriamine n-Hydroxysuccinimide Pentaester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability and prevent hydrolysis of the active ester groups.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.