Description

Diethyl-1,1,1',1'-D4-Stilbestrol-3,3',5,5'-D4 is a high-purity, deuterium-labeled analog of the synthetic estrogen diethylstilbestrol (DES). This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in mass spectrometry. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in method development, pharmacokinetic studies, and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of diethylstilbestrol and related compounds in complex biological matrices like plasma, serum, and tissue homogenates.
• Method Development & Validation: Serves as a stable isotope-labeled reference material for developing and validating sensitive and specific analytical methods in accordance with FDA, EMA, and ICH guidelines.
• Metabolite Tracing & Pharmacokinetics: Enables precise tracking of drug metabolism and accurate determination of pharmacokinetic parameters (AUC, Cmax, Tmax) in preclinical and clinical studies.
• Veterinary & Food Safety Analysis: Used in testing laboratories to monitor for the illegal use of diethylstilbestrol as a growth promoter in livestock and to ensure food safety compliance.
• Environmental Monitoring: Applied in the analysis of environmental samples for endocrine-disrupting chemical residues.
• Certified Reference Material (CRM): A key component in the production of certified reference materials for quality control and proficiency testing programs.

Basic Information

Product Name	Diethyl-1,1,1',1'-D4-Stilbestrol-3,3',5,5'-D4
CAS No.	91318-10-4
Molecular Formula	C18D8H12O2
Molecular Weight	272.38 g/mol
Synonyms	Diethylstilbestrol-d8; DES-d8; (E)-4,4'-(1,2-Diethyl-1,2-d4-ethene-1,1,2,2-d4-diyl)diphenol; 3,4-Bis(4-hydroxyphenyl)-3-hexene-3,4,5,5-d4; Stilbestrol-d8; Didesethylstilbestrol-d8 (incorrect but common); Deuterated Diethylstilbestrol; Diethylstilboestrol-d8
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity to ensure optimal performance as an internal standard. Comprehensive characterization is performed using techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, listing batch-specific data for isotopic enrichment, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For short-term use, storage at 2-8°C is acceptable.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.