Description

Teicoplanin A2-5 is a naturally occurring glycopeptide antibiotic complex isolated from Actinoplanes teichomyceticus, with Teicoplanin A2-5 representing the major biologically active component. It exhibits potent bactericidal activity against Gram-positive bacteria—including methicillin-resistant Staphylococcus aureus (MRSA) and enterococci—making it a critical alternative to vancomycin in clinical and research settings. This high-purity pharmaceutical-grade material is essential for antibiotic development, reference standard use in QC laboratories, and mechanistic microbiological studies. Teicoplanin A2-5 CAS NO 91032-38-1 is supplied under strict quality controls to meet global regulatory expectations for potency, identity, and stability.

Application

• Pharmaceutical reference standard for HPLC and LC-MS assay validation and calibration
• Active pharmaceutical ingredient (API) in the development of intravenous anti-infective formulations
• Research tool for studying bacterial cell wall biosynthesis inhibition and resistance mechanisms
• Quality control standard in compendial testing (USP, EP, JP) for teicoplanin drug substance and products
• Microbiological assay standard for potency determination in antibiotic susceptibility testing
• Stability-indicating method development for glycopeptide degradation pathway analysis
• Comparative pharmacokinetic and pharmacodynamic studies versus vancomycin and newer glycopeptides
• Raw material in GMP-compliant manufacturing of sterile lyophilized teicoplanin preparations

Basic Information

Product Name	Teicoplanin A2-5
CAS No.	91032-38-1
Molecular Formula	C88H102N10O34S
Molecular Weight	1879.9 g/mol
Synonyms	Teicoplanin A2-5; Teicoplanin A2; Teicoplanin A-2-5; Teicoplanin aglycone derivative; Teicoplanin component A2-5; T-A2-5; LY127763; Teicoplaninum A2-5; Teicoplanin A2-5 (EP Reference Standard); Teicoplanin A2-5 (USP Reference Standard)
EINECS	Not listed (EC number not assigned)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to USP Monograph <1058> Analytical Instrument Qualification and ICH Q5, Q6, and Q7 guidelines for biotechnological/biological products. Testing includes identity confirmation (IR, HPLC co-elution), assay (HPLC), related substances (HPLC), residual solvents (GC), heavy metals (USP <231>), and microbiological purity (USP <61> <62>). Full traceability and GMP-aligned documentation support regulatory submissions worldwide.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent oxidation and moisture uptake. Due to its hygroscopic nature, minimize exposure to ambient humidity and avoid repeated opening of the container. Maintain desiccated conditions during handling.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference spectrum (USP/EP)
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	95.0–102.0% (as-is basis)
Related Substances (HPLC)	Individual impurities ≤ 1.0%; Total impurities ≤ 3.0%
Water (Karl Fischer)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Total aerobic count ≤ 100 CFU/g; Absence of E. coli, Salmonella, and S. aureus

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.