Description

6-Thioguanine Disulfide is a dimeric derivative of the purine analog 6-thioguanine, characterized by a disulfide bridge linking two thioguanine moieties. This compound is of significant interest in pharmaceutical research and development, particularly as a potential prodrug or intermediate in the synthesis of novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers focused on oncology drug discovery and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and synthesis of novel antimetabolite drugs and prodrugs targeting various cancers.
• Biochemical Research: Used as a reference standard or probe in studies investigating purine metabolism, nucleotide analog mechanisms, and redox biology.
• Organic Synthesis: Acts as a specialized reagent for introducing the thioguanine pharmacophore or disulfide functional groups into more complex molecular architectures.
• Preclinical Development: Employed in the formulation and testing of new therapeutic candidates in laboratory and animal studies.

Basic Information

Product Name	6-Thioguanine Disulfide
CAS No.	90920-73-3
Molecular Formula	C10H12N10S4
Molecular Weight	400.47 g/mol
Synonyms	6-TG Disulfide; 2-Amino-1,7-dihydro-6H-purine-6-thione Disulfide; Bis(2-amino-6-purinyl) Disulfide; 6-Thioguanine Dimer; 6-Mercaptoguanine Disulfide; NSC 752; Thioguanine Disulfide
EINECS	Contact for details

Quality Control

Our 6-Thioguanine Disulfide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.