Description

H-Ala-Arg-βna · 2 Hcl is a protected dipeptide derivative, specifically the hydrochloride salt form of an alanine-arginine sequence coupled to a β-naphthylamide group. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled construction of complex peptides and proteins for research and development. It is primarily utilized by pharmaceutical researchers, biochemists, and fine chemical manufacturers engaged in peptide-based drug discovery, proteomics studies, and the production of specialized bioactive compounds.

Application

• Peptide Synthesis Intermediate: A key protected fragment for the stepwise assembly of longer peptide chains in both research and GMP manufacturing settings.
• Pharmaceutical Research & Development: Used as a building block for creating novel peptide therapeutics, including potential enzyme inhibitors, receptor agonists/antagonists, and diagnostic agents.
• Biochemical Research: Employed in proteomics and enzymology studies to investigate substrate specificity, enzyme kinetics, and protein-protein interactions.
• API Development: Serves as a critical raw material in the development and scale-up of Active Pharmaceutical Ingredients (APIs) with peptide backbones.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke peptide synthesis services.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method validation in peptide analysis.

Basic Information

Product Name	H-Ala-Arg-βna · 2 Hcl
CAS No.	90836-22-9
Molecular Formula	C19H30N6O3 · 2HCl
Molecular Weight	479.40 g/mol (free base)
Synonyms	H-Ala-Arg-2-Naphthylamide dihydrochloride; Alanine-Arginine-β-Naphthylamide dihydrochloride; L-Alanyl-L-arginine-2-naphthylamide dihydrochloride; Ala-Arg-βNA · 2HCl; H-Ala-Arg-2NA · 2HCl; Peptide Synthesis Building Block 90836-22-9; N-[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]naphthalen-2-amine dihydrochloride
EINECS	Contact for details

Quality Control

Our H-Ala-Arg-βna · 2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via mass spectrometry and NMR. We provide Certificates of Analysis (COA) with detailed batch-specific results to ensure traceability and compliance with your research or production requirements. Specifications can be tailored to meet the needs of various applications, from standard research grade to GMP-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	97.0% - 103.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.