Description

(S)-(+)-n-(3,5-Dinitrobenzoyl)-α-Phenylglycine is a high-purity chiral derivatizing agent and resolving reagent, essential for the separation and analysis of enantiomers. Its core value lies in its ability to form stable diastereomeric complexes with racemic amines and amino acids, enabling precise chiral resolution via chromatography or crystallization. This compound is critically needed by pharmaceutical R&D laboratories, analytical service providers, and fine chemical manufacturers focused on developing and producing single-enantiomer active pharmaceutical ingredients (APIs).

Application

• Chiral derivatizing agent for the HPLC and LC-MS analysis of enantiomeric purity in pharmaceutical compounds.
• Resolving reagent for the preparative-scale separation of racemic amines and amino acids via diastereomeric salt formation.
• Key intermediate in the synthesis of advanced chiral stationary phases (CSPs) for analytical and preparative chromatography.
• Critical tool in asymmetric synthesis research and method development for stereochemistry studies.
• Used in quality control laboratories to ensure enantiomeric excess (ee) in chiral drug substances and intermediates.
• Application in the development and validation of chiral separation methods compliant with ICH guidelines.

Basic Information

Product Name	(S)-(+)-n-(3,5-Dinitrobenzoyl)-α-Phenylglycine
CAS No.	90761-62-9
Molecular Formula	C15H11N3O7
Molecular Weight	345.27 g/mol
Synonyms	(S)-(+)-N-(3,5-Dinitrobenzoyl)phenylglycine; (S)-N-(3,5-Dinitrobenzoyl)-α-phenylglycine; (S)-α-Phenyl-N-(3,5-dinitrobenzoyl)glycine; DNBPG; (S)-(+)-DNB-PG; Dinitrobenzoylphenylglycine; (S)-DNBPG; Chiral Derivatization Reagent DNBPG
EINECS	Contact for details

Quality Control

Our (S)-(+)-n-(3,5-Dinitrobenzoyl)-α-Phenylglycine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, standard pharmacopeial identification tests, and impurity profiling. A Certificate of Analysis (COA) detailing purity, specific rotation, and chromatographic data is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]20/D	+140° to +150° (c=1 in DMF)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.