Description

(S)-(-)-1-Phenylethanol CAS NO 1445-91-6 is a high-purity chiral alcohol, specifically the (S)-enantiomer of 1-phenylethanol, serving as a critical building block in asymmetric synthesis. Its defined stereochemistry is essential for producing optically active pharmaceuticals, agrochemicals, and specialty chemicals with high enantiomeric purity. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical, fragrance, and fine chemical industries who require a reliable source of a key chiral intermediate.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key starting material or resolving agent for the production of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system.
• Asymmetric Catalyst Ligand Precursor: Used in the synthesis of chiral ligands for transition metal catalysts employed in enantioselective hydrogenation and other catalytic reactions.
• Fragrance and Flavor Ingredient: Imparts a floral, rose-like aroma and is used in the formulation of high-end perfumes and flavor compositions where optical purity affects the scent profile.
• Agrochemical Intermediate: Employed in the synthesis of chiral pesticides and herbicides to enhance biological activity and reduce environmental impact.
• Research & Development: A standard reagent in academic and industrial R&D for studying stereoselective reactions, enzymatic resolutions, and chiral pool syntheses.
• Polymer Modification: Acts as a chiral monomer or chain transfer agent in the synthesis of specialty polymers with specific optical properties.

Basic Information

Product Name	(S)-(-)-1-Phenylethanol
CAS No.	1445-91-6
Molecular Formula	C8H10O
Molecular Weight	122.16 g/mol
Synonyms	(S)-1-Phenylethanol; (S)-(-)-α-Methylbenzyl Alcohol; (S)-(-)-Methylphenylcarbinol; (S)-(-)-1-Phenylethyl Alcohol; (S)-PEA; L-1-Phenylethanol; (S)-α-Phenylethyl Alcohol; (1S)-1-Phenylethan-1-ol
EINECS	215-896-3

Quality Control

Our (S)-(-)-1-Phenylethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and GC analysis, to ensure high chemical and enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, specific rotation, and impurity profiles to support your quality assurance protocols. Our production adheres to cGMP principles where applicable, ensuring consistency and traceability for demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]20/D	-45° to -48° (c=1 in ethanol)
Water Content (KF)	≤ 0.5%
Refractive Index n20/D	1.525 - 1.529

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.