Description

(S)-(-)-5,5',6,6'-Tetramethyl-3,3'-Di-tert-Butyl-1,1'-Biphenyl-2,2'-Diol is a high-purity, chiral biphenol derivative widely recognized as a privileged ligand and catalyst precursor in asymmetric synthesis. Its value lies in its ability to impart exceptional stereoselectivity in critical organic transformations, enabling the production of enantiomerically pure compounds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance chiral auxiliaries for process development and advanced material synthesis.

Application

• As a chiral ligand for transition metal catalysts in asymmetric hydrogenation, oxidation, and cross-coupling reactions.
• As a key building block for the synthesis of chiral phosphoramidite and phosphite ligands used in industrial-scale enantioselective catalysis.
• In the research and development of novel active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• For the preparation of chiral stationary phases (CSPs) used in analytical and preparative chromatography for enantiomer separation.
• As a precursor in the synthesis of advanced polymeric materials with specific chiral or helical structures.
• In agrochemical research for creating enantiomerically pure herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	(S)-(-)-5,5',6,6'-Tetramethyl-3,3'-Di-tert-Butyl-1,1'-Biphenyl-2,2'-Diol
CAS No.	101203-31-0
Molecular Formula	C28H42O2
Molecular Weight	410.63 g/mol
Synonyms	(S)-VAPOL; (S)-(-)-2,2'-Dihydroxy-3,3'-di-tert-butyl-5,5',6,6'-tetramethyl-1,1'-biphenyl; (S)-VAPOL Ligand; (S)-5,5',6,6'-Tetramethyl-3,3'-di-tert-butylbiphenyl-2,2'-diol; (S)-VAPOL (Biphenol); VAPOL, (S)-(-)-; (S)-VAPOL (BINOL analog); (S)-2,2'-Dihydroxy-5,5',6,6'-tetramethyl-3,3'-di-tert-butyl-1,1'-biphenyl
EINECS	Contact for details

Quality Control

Our (S)-(-)-5,5',6,6'-Tetramethyl-3,3'-Di-tert-Butyl-1,1'-Biphenyl-2,2'-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure compliance with stringent research and process chemistry requirements. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and chiral purity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain optimal purity and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.