Description

(S)-α-tert-Butyl-o-Methylbenzylamine CAS NO 100485-66-3 is a high-purity, single-enantiomer chiral amine building block of significant importance in asymmetric synthesis. Its value lies in its rigid, bulky tert-butyl group adjacent to the stereogenic center, which provides excellent stereochemical control in catalytic reactions and chiral resolution processes. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require a reliable, high-quality source of this specific chiral auxiliary for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• As a key chiral ligand or catalyst precursor in asymmetric hydrogenation and other transition metal-catalyzed reactions.
• As a chiral resolving agent for the separation of racemic mixtures of carboxylic acids and other acidic compounds.
• As a versatile building block in pharmaceutical synthesis, particularly for creating molecules with defined stereochemistry for central nervous system (CNS) and cardiovascular drugs.
• In the research and development of novel agrochemicals where specific stereochemistry is required for biological activity.
• For the synthesis of advanced materials and specialty polymers that incorporate chiral elements for specific optical or mechanical properties.
• As a reference standard and intermediate in analytical chemistry and process development within quality control and R&D laboratories.

Basic Information

Product Name	(S)-α-tert-Butyl-o-Methylbenzylamine
CAS No.	100485-66-3
Molecular Formula	C12H19N
Molecular Weight	177.29 g/mol
Synonyms	(S)-(-)-α-(1,1-Dimethylethyl)benzenemethanamine; (S)-α-tert-Butylbenzylamine; (S)-1-(1,1-Dimethylethyl)-1-phenylethanamine; (S)-1-Phenyl-2-tert-butylethylamine; (S)-ATBBA; (S)-(-)-α-(tert-Butyl)benzylamine; (S)-1-Phenylethyl-tert-butylamine; (S)-1-(tert-Butyl)-1-phenylethylamine
EINECS	Contact for details

Quality Control

Our (S)-α-tert-Butyl-o-Methylbenzylamine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity (enantiomeric excess), and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere such as nitrogen to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.