Description

(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether is a high-value, chiral organosilicon compound that serves as a crucial ligand and catalyst precursor in asymmetric synthesis. Its significance lies in its ability to induce high enantioselectivity in a variety of carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the production of optically pure pharmaceutical intermediates and fine chemicals. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity chiral auxiliaries.

Application

• Asymmetric Catalysis: As a key ligand for metals like rhodium, iridium, and copper in enantioselective hydrogenation, conjugate addition, and allylic substitution reactions.
• Pharmaceutical Intermediate Synthesis: For the production of chiral active pharmaceutical ingredients (APIs), particularly in routes requiring prolinol-derived catalysts.
• Agrochemical Manufacturing: In the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Methodology Development: A valuable tool for academic and industrial research in developing new asymmetric synthetic protocols.
• Ligand Library Construction: Serves as a sophisticated building block for creating diverse chiral ligand libraries for high-throughput catalyst screening.
• Fine Chemical Production: Enables the asymmetric synthesis of specialty chemicals, flavors, and fragrances.

Basic Information

Item	Details
Product Name	(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine
CAS No.	848821-61-4
Molecular Formula	C30H28F12NOSi
Molecular Weight	674.63 g/mol
Synonyms	(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine; (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether; (S)-3,5-Bis(trifluoromethyl)phenylprolinol TMS ether; (S)-DTBM-Prolinol TMS Ether; (S)-Bis(3,5-di(trifluoromethyl)phenyl)(trimethylsilyloxy)methyl pyrrolidine; (S)-Prolinol Silyl Ether Derivative; Chiral Prolinol-Based Silyl Ether Ligand; CAS 848821-61-4
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and analyzed under strict quality management protocols to ensure consistency and high performance in catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing chiral purity, chemical purity, and identity confirmation. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries, ensuring traceability and reliability for your critical asymmetric synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and prevent decomposition. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.