Description

(17Beta)-4,17-Dihydroxyestra-1,3,5(10)-Trien-3-Yl β-D-Glucopyranosiduronic Acid CAS NO 90746-94-4 is a specific, high-purity conjugated metabolite of estradiol, formed via glucuronidation. This compound is critical for research and development in endocrinology and pharmacology, serving as a definitive reference standard. It is primarily needed by pharmaceutical R&D laboratories, clinical diagnostic manufacturers, and academic institutions focused on steroid hormone metabolism, bioanalytical method development, and pharmacokinetic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified primary standard for the quantitative analysis of estradiol metabolites in drug development and bioequivalence studies.
• Clinical Diagnostics: Essential for calibrating and validating LC-MS/MS and immunoassay systems used to measure hormone levels in patient serum and urine samples.
• Metabolic Pathway Research: A key tool for investigating Phase II conjugation pathways, enzyme kinetics of UDP-glucuronosyltransferases (UGTs), and steroid disposition.
• Toxicology & Doping Control: Employed as a marker compound in forensic and sports anti-doping laboratories to detect and confirm the presence of endogenous steroids.
• Biomarker Development: Supports the discovery and validation of hormonal biomarkers for endocrine-related cancers and disorders.

Basic Information

Product Name	(17Beta)-4,17-Dihydroxyestra-1,3,5(10)-Trien-3-Yl β-D-Glucopyranosiduronic Acid
CAS No.	90746-94-4
Molecular Formula	C24H32O9
Molecular Weight	464.51 g/mol
Synonyms	Estradiol 3-Glucuronide; 17β-Estradiol 3-Glucuronide; E2-3G; E2-3-Gluc; Estra-1,3,5(10)-triene-3,17β-diol 3-glucuronide; 17β-Estra-1,3,5(10)-triene-3,17-diol 3-(β-D-glucopyranosiduronic acid); 3-Hydroxyestra-1,3,5(10)-trien-17-one 3-glucuronide (related form); Estrogen metabolite 3-Gluc
EINECS	Contact for details

Quality Control

Every batch of (17Beta)-4,17-Dihydroxyestra-1,3,5(10)-Trien-3-Yl β-D-Glucopyranosiduronic Acid is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that include data for identity, purity (HPLC), and specific impurities. Our standards are suitable for use in regulated environments, supporting compliance with GMP, ICH Q7, and relevant pharmacopeial guidelines for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.