Description

D-Mannitol-[1-3H(N)] CAS NO 90358-49-9 is a tritium-labeled derivative of the sugar alcohol D-mannitol, specifically labeled at the 1-position. This compound is essential for advanced research and development, providing a critical tool for metabolic and pharmacokinetic studies where precise tracking is required. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and academic institutions engaged in life science research.

Application

• Tracer Studies in Metabolism: Used as a radioactive tracer to investigate the metabolic pathways and distribution of mannitol and related compounds in biological systems.
• Pharmacokinetic Research: Enables detailed ADME (Absorption, Distribution, Metabolism, Excretion) studies for drug candidates that utilize mannitol as an excipient or active component.
• Biochemical Assay Development: Serves as a labeled standard in the development and validation of sensitive analytical methods, such as liquid scintillation counting (LSC) and HPLC-MS.
• Medical and Diagnostic Research: Applied in research related to renal function, blood-brain barrier permeability, and as a probe in various physiological studies.
• Quality Control & Process Validation: Acts as an internal standard in analytical laboratories for ensuring the accuracy and precision of assays in pharmaceutical manufacturing.

Basic Information

Product Name	D-Mannitol-[1-3H(N)]
CAS No.	90358-49-9
Molecular Formula	C6H14O6 (³H labeled)
Molecular Weight	~185.2 g/mol (³H labeled)
Synonyms	Mannitol-1-³H; [1-³H]Mannitol; Tritiated D-Mannitol; 1-Tritio-D-mannitol; D-Mannitol (1-tritiated); Hexahydroxyhexane-1-³H; Radioactive Mannitol; Mannitol (³H)
EINECS	Contact for details

Quality Control

Every batch of D-Mannitol-[1-3H(N)] is produced and analyzed under strict quality control protocols to ensure high chemical and radiochemical purity, specific activity, and stability. Certificates of Analysis (COA) are provided, detailing parameters such as radionuclidic purity, radiochemical purity (typically by HPLC), specific activity, and chemical identification. Our quality system is designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures, typically 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure containers are sealed properly after use to prevent absorption of moisture. For long-term storage, consider conditions recommended for radioactive materials. Keep away from incompatible substances.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Customizable (e.g., 10-50 Ci/mmol)
Solvent (if supplied in solution)	Specified (e.g., Ethanol:Water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.