Description

Seneciphyllinine is a pyrrolizidine alkaloid (PA) of significant interest in research and analytical chemistry. This compound is primarily utilized as a high-purity reference standard for the identification and quantification of toxic pyrrolizidine alkaloids in complex matrices. It serves critical roles in the pharmaceutical, botanical, and food safety industries, where precise analytical methods are required for quality control and regulatory compliance.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for method development and validation in HPLC, LC-MS, and GC-MS analyses.
• Phytochemical Research: Used in the study of plant biochemistry, alkaloid biosynthesis pathways, and the toxicological profiling of botanical extracts.
• Food & Feed Safety Testing: Essential for detecting and quantifying pyrrolizidine alkaloid contaminants in honey, herbal teas, spices, and dietary supplements to ensure consumer safety.
• Pharmaceutical Impurity Profiling: Employed in the quality control of herbal medicines and phytopharmaceuticals to monitor and control the presence of potentially hepatotoxic PAs.
• Toxicological Studies: Serves as a precise standard in in-vitro and in-vivo research to understand the metabolism, toxicity, and biological activity of senecionine-type alkaloids.
• Regulatory Compliance & Method Certification: Used by testing laboratories to comply with international regulations (e.g., EMA, EFSA, USP) regarding PA limits in consumer products.

Basic Information

Product Name	Seneciphyllinine
CAS No.	90341-45-0
Molecular Formula	C18H25NO5
Molecular Weight	335.40 g/mol
Synonyms	Seneciphylline; 12-Hydroxysenecionan-11,16-dione; (1R,4R,7S,8R,13R,14R,17R)-4,7-Dimethyl-14-(1-methylethyl)-10,15-dioxo-11-oxa-3-azapentacyclo[9.5.2.01,8.04,7.013,17]octadecan-6-yl acetate; Senecionine 12-hydroxy derivative; PA Reference Standard
EINECS	Contact for details

Quality Control

Our Seneciphyllinine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for reference materials. A detailed Certificate of Analysis (COA) is provided, which includes batch-specific data on purity, impurities, and chromatographic profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.