Description

6-((4-Bromo-2,3-Dioxobutyl)Thio)-6-Deaminoadenosine 5'-Diphosphate is a chemically modified nucleotide analog, specifically an adenosine derivative, designed for advanced biochemical research and development. This compound is a critical tool for studying enzyme mechanisms, particularly those involving nucleotide-binding proteins and kinases, due to its reactive bromodioxobutyl moiety. It is primarily utilized by research scientists and process developers in the pharmaceutical and biotechnology sectors for target identification, inhibitor screening, and probing metabolic pathways.

Application

• Enzyme Inhibition Studies: Acts as a mechanism-based inhibitor or affinity label for enzymes that utilize ATP or ADP as substrates, such as kinases and dehydrogenases.
• Biochemical Probe Development: Serves as a key intermediate in the synthesis of active site-directed probes for proteomics and chemical biology research.
• Pharmaceutical Research: Used in high-throughput screening (HTS) campaigns to identify and characterize novel therapeutic targets and lead compounds.
• Metabolic Pathway Analysis: Employed to investigate nucleotide metabolism and signaling pathways within cells.
• Academic Research: A valuable reagent for universities and research institutes studying protein structure, function, and regulation.
• Diagnostic Reagent Synthesis: Can be used as a precursor in the development of specialized diagnostic assays and kits.

Basic Information

Product Name	6-((4-Bromo-2,3-Dioxobutyl)Thio)-6-Deaminoadenosine 5'-Diphosphate
CAS No.	90269-32-2
Molecular Formula	C₁₄H₁₇BrN₄O₁₂P₂S
Molecular Weight	623.22 g/mol
Synonyms	6-[(4-Bromo-2,3-dioxobutyl)thio]-6-deaminoadenosine 5'-diphosphate; 6-(4-Bromo-2,3-dioxobutylthio)-6-deaminoadenosine diphosphate; 6-BDB-TADP; 6-((4-Bromo-2,3-dioxobutyl)thio)adenosine 5'-diphosphate analog; Modified ADP analog; Reactive nucleotide probe; Bromodioxobutyl-ADP
EINECS	Contact for details

Quality Control

Our 6-((4-Bromo-2,3-Dioxobutyl)Thio)-6-Deaminoadenosine 5'-Diphosphate is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.