Description

1-Bromo-4-((9-(5-o-Phosphono-β-D-Ribofuranosyl)-9H-Purin-6-Yl)Thio)-2,3-Butanedione is a sophisticated, high-purity nucleotide analog derivative designed for advanced research and development. This compound is critical for scientists working in medicinal chemistry and biochemistry, particularly in the development of novel enzyme inhibitors and probes for studying purinergic signaling pathways. Its primary value lies in its role as a key synthetic intermediate or active pharmaceutical ingredient (API) precursor for targeted therapeutic applications. This product is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on oncology, virology, and metabolic disease research.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Biochemical Research: Used as a substrate analog or inhibitor in enzymatic studies, particularly those involving kinases, phosphotransferases, and other ATP-binding proteins.
• Probe Development: Acts as a precursor for developing labeled probes (e.g., fluorescent or radioactive) for cellular imaging and target engagement studies in drug discovery.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates targeting purine receptors.
• Reference Standard: Provides a high-purity compound for use as an analytical standard in quality control and method development for API manufacturing.

Basic Information

Product Name	1-Bromo-4-((9-(5-o-Phosphono-β-D-Ribofuranosyl)-9H-Purin-6-Yl)Thio)-2,3-Butanedione
CAS No.	90269-31-1
Molecular Formula	C₁₄H₁₆BrN₅O₉PS
Molecular Weight	549.25 g/mol
Synonyms	6-((1-Bromo-2,3-dioxobutyl)thio)-9-(5-O-phosphono-β-D-ribofuranosyl)-9H-purine; 6-[(1-Bromo-2,3-dioxobutyl)thio]-9-(5-O-phosphono-β-D-ribofuranosyl)purine; 1-Bromo-4-[(9-(5-O-phosphono-β-D-ribofuranosyl)-9H-purin-6-yl)thio]-2,3-butanedione; Purine nucleoside phosphonate derivative; Thiopurine nucleotide analog; Bromodioxobutyl thiopurine ribotide
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-((9-(5-o-Phosphono-β-D-Ribofuranosyl)-9H-Purin-6-Yl)Thio)-2,3-Butanedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.