Description

Adenosine 5'-(α-Thio)Diphospho-5'-Ribofuranosylnicotinamide is a specialized nucleotide analog of significant interest in biochemical and pharmaceutical research. Its core value lies in its role as a stable, hydrolysis-resistant mimic of NAD(P)H, enabling detailed study of enzymatic mechanisms and redox biology. This compound is essential for researchers and developers in pharmaceutical discovery, enzymology, and diagnostic assay development who require high-purity, well-characterized biochemical tools.

Application

• Enzyme Kinetics & Mechanism Studies: Used as a substrate analog to investigate the catalytic mechanisms of NAD(P)H-dependent dehydrogenases and reductases.
• Pharmaceutical Research: Serves as a key intermediate or probe in the development of novel therapeutics targeting metabolic pathways and redox enzymes.
• Diagnostic Assay Development: Employed in the formulation of sensitive and specific clinical diagnostic kits for monitoring enzyme activities related to metabolic disorders.
• Biochemical Research: Acts as a critical reagent in studying cellular energy metabolism, signal transduction, and oxidative stress responses.
• Cofactor Engineering: Utilized in biocatalysis and synthetic biology to engineer enzymes with altered cofactor specificity or enhanced stability.

Basic Information

Product Name	Adenosine 5'-(α-Thio)Diphospho-5'-Ribofuranosylnicotinamide
CAS No.	90024-63-8
Molecular Formula	C21H29N6O14P2S
Molecular Weight	683.50 g/mol
Synonyms	Thio-NAD; Thionicotinamide Adenine Dinucleotide; Adenosine 5'-(α-Thio)diphospho-5'-ribofuranosylnicotinamide; α-NAD(S); α-Thio-NAD; Nicotinamide Adenine Dinucleotide, Thio Analog; TNAD; NAD(S) α-isomer
EINECS	Contact for details

Quality Control

Our production of Adenosine 5'-(α-Thio)Diphospho-5'-Ribofuranosylnicotinamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.