Description

Aprotinin is a broad-spectrum, naturally occurring polypeptide protease inhibitor derived from bovine lung tissue. Its primary value lies in its potent ability to inhibit serine proteases like trypsin, plasmin, and kallikrein, making it a critical biochemical tool and therapeutic agent. This compound is essential for researchers in biochemistry and pharmacology, as well as manufacturers in the biopharmaceutical sector, particularly for applications in cell culture, protein purification, and the development of anti-inflammatory and anti-hemorrhagic treatments.

Application

• Biochemical Research & In Vitro Diagnostics: Used as a standard protease inhibitor in enzymatic assays, protein isolation, and cell culture media to prevent protein degradation.
• Pharmaceutical Manufacturing: Employed as an active pharmaceutical ingredient (API) in anti-fibrinolytic drugs to reduce perioperative blood loss during major surgeries like cardiac and liver transplants.
• Biopharmaceutical Production: Acts as a protective agent in fermentation and downstream processing to enhance the yield and stability of therapeutic proteins.
• Proteomics & Cell Biology: A key reagent for studying protease-mediated signaling pathways, apoptosis, and inflammation in research laboratories.
• Medical Device Coating: Incorporated into coatings for stents and other implants to improve biocompatibility and reduce inflammatory responses.
• Veterinary Medicine: Used in treatments for animals, mirroring its anti-hemorrhagic applications in human medicine.

Basic Information

Product Name	Aprotinin
CAS No.	9087-70-1
Molecular Formula	C284H432N84O79S7
Molecular Weight	Approx. 6511.5 g/mol
Synonyms	BPTI (Bovine Pancreatic Trypsin Inhibitor); Trypsin Inhibitor, Basic Pancreatic; Kunitz Pancreatic Trypsin Inhibitor; Antikrein; Contrical; Gordox; Trasylol; Zymofren; Protease Inhibitor from Bovine Lung; Kallikrein-Trypsin Inhibitor.
EINECS	Contact for details

Quality Control

Our Aprotinin is produced and tested under strict quality management systems to ensure it meets the high standards required for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, biological activity, and impurity profiles. We can supply material compliant with various pharmacopeial standards, including USP and EP monographs, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White or almost white lyophilized powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 95.0%
Biological Activity	≥ 3.0 USP U/mg (Trypsin inhibition)
Water (Karl Fischer)	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Bacterial Endotoxins	< 0.1 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.