Description

Dihydropteridine Reductase From Sheep Liver is a purified enzyme critical for the regeneration of tetrahydrobiopterin (BH4), an essential cofactor in neurotransmitter synthesis and amino acid metabolism. This high-purity biological reagent is vital for research and diagnostic applications requiring precise enzymatic activity. It is primarily utilized by biochemical researchers, pharmaceutical developers, and diagnostic kit manufacturers in the life sciences sector.

Application

• Biochemical Research: Used as a key reagent in enzymatic studies of phenylalanine, tyrosine, and tryptophan hydroxylation pathways.
• Diagnostic Assay Development: Essential component in in vitro diagnostic kits for the detection and quantification of phenylalanine, aiding in newborn screening for phenylketonuria (PKU).
• Pharmaceutical R&D: Employed in target validation and screening assays for drug discovery programs focused on neurological disorders and metabolic diseases.
• Enzyme Kinetics Studies: Serves as a standard for investigating reductase activity, inhibitor effects, and cofactor regeneration cycles.
• Quality Control Testing: Used as a reference standard in the quality assurance of related pharmaceutical intermediates and diagnostic components.
• Educational Purposes: Supplied to academic institutions for advanced teaching laboratories in enzymology and metabolic biochemistry.

Basic Information

Product Name	Dihydropteridine Reductase From Sheep Liver
CAS No.	9074-11-7
Molecular Formula	Protein (Enzyme)
Molecular Weight	Contact for details
Synonyms	DHPR; Dihydropteridine Reductase (Sheep Liver); NADH-Dihydropteridine Reductase; 6,7-Dihydropteridine:NADP+ Oxidoreductase; EC 1.5.1.34; Pteridine Reductase; Tetrahydrobiopterin Regeneration Enzyme; Quinoid Dihydropteridine Reductase
EINECS	Contact for details

Quality Control

Our Dihydropteridine Reductase is produced and tested under stringent conditions to ensure high specific activity, purity, and batch-to-batch consistency suitable for research and diagnostic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing activity units, protein content, and purity assessments. We adhere to relevant quality management principles to support our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent moisture absorption, which can affect enzymatic activity. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Specific Activity	≥ [Value] units/mg protein
Protein Content (Biuret)	Contact for details
Purity (SDS-PAGE)	≥ 90%
Identification (Activity)	Complies
Solubility	Clear solution in specified buffer
pH (in solution)	7.0 - 7.5
Endotoxin (LAL test)	< 1.0 EU/μg (for diagnostic grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.