Description

Cathepsin E is a non-lysosomal, intracellular aspartic protease that plays a significant role in antigen processing and immune response modulation. Its unique enzymatic activity makes it a valuable tool for biochemical research and a target for therapeutic development. This high-purity enzyme is essential for researchers and manufacturers in the fields of immunology, oncology, and neurodegenerative disease research, where precise proteolytic activity is required.

Application

• Biochemical Research: Used as a specific protease in enzymatic assays to study protein processing and degradation pathways.
• Immunology Studies: Critical for in vitro research on antigen presentation and processing within the endosomal/lysosomal system.
• Drug Discovery & Target Validation: Serves as a molecular target for screening and developing inhibitors for autoimmune diseases and certain cancers.
• Diagnostic Development: Employed in the research and development of diagnostic assays for conditions involving dysregulated protease activity.
• Neuroscience Research: Investigated for its role in amyloid precursor protein processing and its potential link to neurodegenerative disorders.
• Enzyme Characterization: Used in comparative studies with other aspartic proteases like Cathepsin D to understand substrate specificity and inhibitor profiles.

Basic Information

Product Name	Cathepsin E
CAS No.	110910-42-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cathepsin E (Bos taurus); Cathepsin E Precursor; Non-lysosomal Aspartic Protease; Intracellular Aspartic Proteinase; EC 3.4.23.34; Aspartic Protease Cathepsin E; CATE_BOVIN
EINECS	Contact for details

Quality Control

Our Cathepsin E is produced and tested under stringent conditions to ensure high activity, purity, and batch-to-batch consistency suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specific activity, purity level (by SDS-PAGE and/or HPLC), and absence of contaminating proteases. We adhere to rigorous quality management principles to support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted material to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Conforms
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content (Bradford)	Reported on COA
Solubility	Soluble in appropriate aqueous buffers
Endotoxin Level	< 1.0 EU/μg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.