Description

Malonyl Gramicidin is a chemically modified derivative of the classic polypeptide antibiotic gramicidin, where malonyl groups are introduced to alter its physicochemical and biological properties. This modification is significant for fine-tuning its ionophoric activity and membrane interaction, which is critical for advanced research and development applications. It is primarily needed by researchers in pharmaceutical development, biochemistry, and microbiology for studying ion transport mechanisms and developing novel antimicrobial agents.

Application

• Biochemical Research: Used as a model ionophore in studies of transmembrane ion transport, particularly for monovalent cations like potassium and sodium.
• Antimicrobial Studies: Serves as a reference compound or a modified template for investigating structure-activity relationships against Gram-positive bacteria.
• Membrane Biophysics: Employed in the preparation of artificial lipid bilayers and vesicles to probe membrane permeability and stability.
• Pharmaceutical Development: Acts as an intermediate or a lead compound in the synthesis and screening of novel antibiotic candidates with potentially improved profiles.
• Analytical Standards: Utilized as a certified reference material (CRM) in HPLC and mass spectrometry for quality control and method validation in antibiotic analysis.

Basic Information

Product Name	Malonyl Gramicidin
CAS No.	9066-61-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Gramicidin Malonate; Gramicidin A, Malonyl Derivative; Malonylgramicidin; Gramicidin S Malonate (related); Polypeptide Antibiotic Malonate; Ionophore Malonate Derivative; Gramicidin Derivative (Malonylated); Gramicidin Complex Malonate
EINECS	Contact for details

Quality Control

Our Malonyl Gramicidin is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including purity assay and identity confirmation, to ensure it meets the high standards required for research and development purposes. A comprehensive Certificate of Analysis (COA) detailing specific test results is available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.