Description

Hemoglobin M Iwate is a stable, naturally occurring variant of hemoglobin, a critical oxygen-transporting metalloprotein found in red blood cells. This specific mutant form, identified by the CAS number 9035-03-4, is of significant value in biochemical research and diagnostic development due to its unique structural and functional properties. It serves as an essential reference standard and reagent for scientists and manufacturers in the fields of hematology, clinical diagnostics, and advanced biomedical research, enabling studies into hemoglobinopathies and oxygen affinity.

Application

• Biochemical Research Standard: Used as a high-purity reference material for studying hemoglobin structure, function, and mutation effects.
• Clinical Diagnostics Development: Serves as a critical component in the calibration and validation of diagnostic assays for detecting hemoglobin variants and related blood disorders.
• Hematology Studies: Essential for in-vitro research on oxygen-binding kinetics, allosteric regulation, and the pathophysiology of congenital methemoglobinemia.
• Pharmaceutical R&D: Utilized in drug discovery programs targeting sickle cell disease, thalassemia, and other hemoglobin-related conditions.
• Educational & Laboratory Use: Provides a defined mutant hemoglobin for teaching and advanced laboratory techniques in protein chemistry and molecular biology.

Basic Information

Product Name	Hemoglobin M Iwate
CAS No.	9035-03-4
Molecular Formula	C2952H4664N812O832S40Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb M Iwate
Hemoglobin M Boston-Iwate
Methemoglobin M Iwate
α87(F8)His→Tyr Hemoglobin Mutant
HBB Mutant Hemoglobin
Hemoglobin Variant M
Deoxyhemoglobin M Iwate
EINECS	Contact for details

Quality Control

Our Hemoglobin M Iwate is produced and handled under stringent conditions to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including electrophoresis and spectroscopic analysis, to confirm identity and purity. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment, supporting compliance with rigorous laboratory standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. Under these conditions, the product remains stable for extended periods.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Electrophoresis)	Conforms to standard for Hb M Iwate
Purity (HPLC)	≥ 95% (by area)
Protein Content (Biuret)	≥ 90%
Methemoglobin Content (Spectroscopy)	≥ 85%
Solubility	Clear solution in buffer
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.