Description

Thymidylatesynthase CAS NO 9031-61-2 is a critical enzyme involved in the biosynthesis of thymidine monophosphate (dTMP), an essential precursor for DNA synthesis. Its primary commercial and research value lies in its role as a key target for chemotherapeutic agents, particularly in cancer treatment strategies. This product is essential for pharmaceutical R&D, biochemical research, and the development of diagnostic assays targeting nucleotide metabolism pathways.

Application

• Anticancer Drug Discovery & Development: Primary target for fluoropyrimidine-based chemotherapeutics (e.g., 5-Fluorouracil) and novel inhibitor screening.
• Biochemical & Enzymology Research: Used in studies of nucleotide metabolism, enzyme kinetics, and folate cycle mechanisms.
• Diagnostic Kit Manufacturing: A key component in kits designed to measure enzyme activity for research or clinical diagnostic purposes.
• Academic & Pharmaceutical R&D: Fundamental reagent for investigating cell proliferation, DNA replication, and mechanisms of drug resistance.
• Target Validation Studies: Employed in cellular and molecular biology assays to validate Thymidylate Synthase as a therapeutic target.

Basic Information

Product Name	Thymidylatesynthase
CAS No.	9031-61-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Thymidylate Synthase; TS; TMP Synthase; Thymidylate Synthetase; dTMP Synthase; 5,10-Methylenetetrahydrofolate:dUMP C-Methyltransferase; EC 2.1.1.45
EINECS	Contact for details

Quality Control

Our Thymidylatesynthase is produced and tested under stringent conditions to ensure high activity, purity, and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specific activity, purity level (via SDS-PAGE), and functional assay results. We adhere to rigorous internal quality standards to support reliable and reproducible scientific outcomes. COAs are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Activity)	Functional enzyme activity confirmed
Purity (SDS-PAGE)	≥ 90%
Specific Activity	Contact for details
Protein Concentration	Contact for details
Buffer Composition	Specified on COA
Endotoxin Level	< 1.0 EU/µg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.