Description

L-Aspartase is a highly specific enzyme that catalyzes the deamination of L-aspartic acid to fumaric acid and ammonia, serving as a critical biocatalyst in the synthesis of chiral amino acids and other fine chemicals. Its precise stereoselectivity makes it invaluable for producing high-purity intermediates where optical purity is paramount. This enzyme is essential for manufacturers in the pharmaceutical, food & beverage, and biotechnology industries, particularly for the production of aspartame and various L-aspartate-derived compounds.

Application

• Pharmaceutical Synthesis: Key biocatalyst for the production of chiral intermediates and active pharmaceutical ingredients (APIs), especially in the synthesis of aspartame and other amino acid-based drugs.
• Food & Beverage Industry: Used in the enzymatic production of the sweetener aspartame and for the modification of food proteins to enhance flavor or functional properties.
• Biocatalysis & Fine Chemicals: Employed in organic synthesis for the stereoselective amination of fumarate to produce L-aspartic acid, a building block for various specialty chemicals.
• Diagnostic Reagents: A component in enzymatic assay kits for clinical and research laboratories to measure L-aspartate or ammonia levels.
• Biotechnology Research: Used as a model enzyme in biochemical studies of enzyme kinetics, structure-function relationships, and immobilization techniques.
• Animal Feed Additives: Potential application in the production of feed-grade amino acids to improve nutritional profiles.

Basic Information

Product Name	L-Aspartase
CAS No.	9027-30-9
Molecular Formula	N/A (Enzyme)
Molecular Weight	Approx. 50,000 - 200,000 Da (Subunit-dependent)
Synonyms	Aspartate Ammonia-Lyase; L-Aspartase; Aspartase; L-Aspartate Ammonia-Lyase; EC 4.3.1.1; Fumaric Aminase; Aspartate Deaminase; (S)-Aspartate Ammonia-Lyase
EINECS	Contact for details

Quality Control

Our L-Aspartase is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high catalytic activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as specific activity, protein content, and purity. We adhere to relevant industry guidelines for enzyme preparations to support applications in research and commercial-scale production.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent loss of activity. Avoid repeated freeze-thaw cycles of liquid preparations.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (IR)	Conforms
Specific Activity	> 100 U/mg protein
Protein Content (Biuret)	> 90%
Loss on Drying	< 5.0 %
pH (in solution)	6.5 - 7.5
Heavy Metals (as Pb)	< 10 ppm
Microbial Limit	< 1000 CFU/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.