Description

Mevalonate Kinase CAS NO 9026-52-2 is a crucial enzyme that catalyzes the phosphorylation of (R)-mevalonate, a key step in the mevalonate pathway for isoprenoid biosynthesis. This enzyme is essential for research and development in metabolic studies, particularly those focused on cholesterol synthesis and related disorders. It is primarily utilized by biotechnology firms, pharmaceutical research laboratories, and academic institutions engaged in enzymology, drug discovery, and biochemical pathway analysis.

Application

• Enzymology Research: Fundamental studies on enzyme kinetics, mechanism, and inhibition within the mevalonate pathway.
• Drug Discovery & Screening: Target enzyme for identifying and validating potential inhibitors for cholesterol-lowering agents or treatments for metabolic diseases like mevalonate kinase deficiency.
• Biochemical Assay Development: Used as a critical component in in vitro diagnostic and research assays to measure pathway activity.
• Metabolic Pathway Analysis: Investigation of isoprenoid biosynthesis, which is vital for producing sterols, dolichols, and ubiquinone.
• Academic & Educational Use: A standard reagent for graduate-level teaching and research in biochemistry and molecular biology.
• Biocatalyst Development: Potential use in engineered enzymatic cascades for the synthesis of valuable isoprenoid compounds.

Basic Information

Product Name	Mevalonate Kinase
CAS No.	9026-52-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ATP:Mevalonate 5-Phosphotransferase; Mevalonate 5-Kinase; MVK; Phosphomevalonate Kinase (obsolete); EC 2.7.1.36; (R)-Mevalonate Kinase
EINECS	Contact for details

Quality Control

Our Mevalonate Kinase is produced and tested under stringent conditions to ensure high activity, purity, and batch-to-batch consistency suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specific activity, purity level, and stability data. We adhere to rigorous internal quality standards to guarantee reliable performance in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent moisture absorption, which can affect activity. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Activity)	Conforms
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content (Bradford)	Reported on COA
Buffer Composition	Reported on COA
Stabilizers / Additives	Reported on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.