Description

L-Glutamic Decarboxylase is a crucial pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the irreversible decarboxylation of L-glutamic acid to produce γ-aminobutyric acid (GABA). This reaction is fundamental to the GABAergic system, making the enzyme essential for research and industrial processes focused on neurotransmitter synthesis and regulation. It is a vital biochemical tool for neuroscientists, pharmaceutical developers, and manufacturers in the nutraceutical and food industries seeking to produce or analyze GABA.

Application

• Neurochemical Research: Essential for in vitro studies of GABA synthesis, neuronal signaling pathways, and the mechanisms of neurological disorders.
• Pharmaceutical Development: Used in enzymatic assays for screening potential drugs targeting the GABA system, such as anxiolytics, anticonvulsants, and sedatives.
• Diagnostic Reagent Manufacturing: A key component in clinical diagnostic kits for measuring L-glutamic acid levels or GABA-related metabolic activity.
• Biocatalysis & Synthesis: Employed in the enzymatic production of γ-aminobutyric acid (GABA) for nutraceutical, functional food, and cosmetic applications.
• Food & Beverage Analysis: Utilized in enzymatic methods for the quantitative determination of free glutamic acid (umami flavor) in food products.
• Agricultural Biochemistry: Applied in plant physiology research to study stress responses and GABA's role as a signaling molecule in crops.

Basic Information

Product Name	L-Glutamic Decarboxylase
CAS No.	9024-58-2
Molecular Formula	N/A (Enzyme)
Molecular Weight	Varies by source and preparation
Synonyms	Glutamate Decarboxylase; GAD; L-Glutamate 1-Carboxy-Lyase; EC 4.1.1.15; Glutamic Acid Decarboxylase; GABA Synthesis Enzyme; L-Glutamate Decarboxylase
EINECS	Contact for details

Quality Control

Our L-Glutamic Decarboxylase is produced and tested under stringent quality management systems. Each lot is characterized for critical parameters including specific activity, protein content, and purity to ensure batch-to-batch consistency and performance reliability for your research and process applications. A comprehensive Certificate of Analysis (COA) detailing assay results, storage conditions, and stability data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Activity)	Catalyzes decarboxylation of L-Glutamate to GABA
Specific Activity	≥ [Value] units/mg protein
Protein Content (Biuret)	Contact for details
Purity (SDS-PAGE)	Single major band
pH Optimum	~6.8
Stabilizers	May contain buffer salts (e.g., phosphate, citrate)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.