Description

Ec 4.3.1.5 CAS NO 9024-28-6 is a high-purity enzyme preparation, specifically identified as L-phenylalanine ammonia-lyase (PAL). This biocatalyst is essential for the stereospecific synthesis and degradation of aromatic amino acids, offering a sustainable and efficient alternative to traditional chemical synthesis routes. It is a critical reagent for pharmaceutical R&D, diagnostic manufacturing, and the production of fine chemicals and nutraceuticals.

Application

• Pharmaceutical Intermediate Synthesis: Key biocatalyst for the production of non-natural L-amino acids and chiral intermediates used in active pharmaceutical ingredients (APIs).
• Diagnostic Reagent Manufacturing: Used in enzymatic assay kits for the detection and quantification of L-phenylalanine, crucial for newborn screening (e.g., PKU tests).
• Biocatalysis & Green Chemistry: Enables environmentally friendly synthesis processes in fine chemical production, reducing the need for heavy metals and harsh conditions.
• Nutraceutical & Food Science: Applied in the development of low-phenylalanine food products and specialty amino acid supplements.
• Academic & Industrial Research: Serves as a model enzyme in biochemical studies, metabolic pathway engineering, and enzyme mechanism research.
• Biotechnological Production: Utilized in engineered microbial systems for the biosynthesis of valuable plant-derived compounds like stilbenoids.

Basic Information

Product Name	Ec 4.3.1.5 (L-Phenylalanine Ammonia-Lyase)
CAS No.	9024-28-6
Molecular Formula	N/A (Enzyme)
Molecular Weight	~270-330 kDa (Tetramer, species-dependent)
Synonyms	L-Phenylalanine Ammonia-Lyase; PAL; Phenylalanine Ammonia-Lyase; L-Phenylalanine Deaminase; EC 4.3.1.5; Phenylalanine Ammonia-Lyase (L-Phenylalanine Deaminating); 9024-28-6; L-PAL; (S)-2-Amino-3-phenylpropanoate Ammonia-Lyase.
EINECS	Contact for details

Quality Control

Our L-Phenylalanine Ammonia-Lyase (PAL) is produced and tested under stringent quality management systems. Each batch is characterized for specific activity, purity, and stability to ensure reproducible performance in sensitive applications. A comprehensive Certificate of Analysis (COA) detailing activity (U/mg), protein content, and purity assessments is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Specific Activity	≥ 2 U/mg protein
Protein Content (Biuret)	≥ 90%
Identification (Activity)	Conforms
pH Optimum	8.5 - 9.5
Temperature Optimum	40 - 55 °C
Stability	Stable for 24 months at -20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.