Description

Chondroitinase Abc CAS NO 9024-13-9 is a highly purified enzyme preparation derived from *Proteus vulgaris*, specifically engineered to cleave chondroitin sulfate glycosaminoglycans. This product is critical for research and development in neuroscience and regenerative medicine, where precise modification of the extracellular matrix is required. It is an essential tool for pharmaceutical developers, academic researchers, and biotech companies focused on spinal cord injury models, tissue engineering, and the study of proteoglycan biology.

Application

• Neuroscience Research: Used to digest chondroitin sulfate proteoglycans (CSPGs) in experimental models of spinal cord injury and nerve regeneration to reduce glial scar formation and promote axonal growth.
• Biochemical Analysis: Employed in the structural analysis and sequencing of chondroitin sulfate chains to understand sulfation patterns and glycosaminoglycan function.
• Tissue Engineering & Regenerative Medicine: Applied to modify scaffold materials by removing inhibitory CSPGs, creating a more permissive environment for cell adhesion and tissue repair.
• Pharmaceutical Development: Serves as a key reagent in screening assays and preclinical studies for therapies targeting extracellular matrix disorders.
• Diagnostic Reagent Manufacturing: Utilized in the production of kits for the detection and quantification of specific glycosaminoglycans in biological samples.

Basic Information

Product Name	Chondroitinase Abc
CAS No.	9024-13-9
Molecular Formula	N/A (Enzyme)
Molecular Weight	~100-120 kDa (Protein)
Synonyms	Chondroitin ABC Lyase; Chondroitinase ABC; Chondroitin ABC Eliminase; Chondroitin Sulfate ABC Lyase; Chondroitin Sulfate ABC Eliminase; Chondroitinase from *Proteus vulgaris*; CAS 9024-13-9
EINECS	Contact for details

Quality Control

Our Chondroitinase Abc is produced under stringent conditions to ensure high specific activity and purity, suitable for sensitive research applications. Each lot is tested for enzymatic activity, protein content, and the absence of contaminating protease and nuclease activities. A comprehensive Certificate of Analysis (COA) detailing purity, activity (units/mg), and stability is provided with every shipment to guarantee batch-to-batch consistency and performance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C. Reconstituted enzyme solutions should be aliquoted and stored at -70°C or below to prevent activity loss. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Cleaves chondroitin sulfate A, B, and C
Specific Activity	≥ 0.5 - 2.0 units/mg protein (Lot-specific)
Protein Content (Biuret)	≥ 90%
Purity (SDS-PAGE)	Single major band
Protease Activity	Not detected
Nuclease Activity	Not detected
Solubility	Soluble in water or appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.