Description

Dtmp Kinase is a specialized enzyme critical for catalyzing the phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), a key step in the biosynthesis of DNA precursors. This makes it an essential reagent in biochemical research and pharmaceutical development, particularly in studies related to nucleotide metabolism, cell proliferation, and antiviral or anticancer drug discovery. Key industries that rely on this high-purity enzyme include biotechnology, academic research institutions, and pharmaceutical companies engaged in molecular biology and enzymology.

Application

• Biochemical Research: Used as a critical reagent in enzymatic assays to study nucleotide metabolism and kinase activity.
• Pharmaceutical Development: Employed in screening and development of novel inhibitors targeting nucleotide biosynthesis pathways for antiviral and anticancer therapies.
• Molecular Biology: Essential for in vitro DNA synthesis studies and understanding the regulation of the thymidylate cycle.
• Diagnostic Kit Manufacturing: Incorporated into enzymatic diagnostic kits for measuring dTMP kinase activity in clinical and research samples.
• Enzyme Characterization: Serves as a standard or subject for studies on enzyme kinetics, structure, and function.
• Academic & Industrial R&D: A fundamental tool for laboratories investigating DNA replication, repair mechanisms, and related cellular processes.

Basic Information

Product Name	Dtmp Kinase
CAS No.	9014-43-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Thymidylate Kinase; dTMP Kinase; Thymidine Monophosphate Kinase; Thymidylate Kinase (phosphorylating); ATP:thymidine-5'-phosphate phosphotransferase; EC 2.7.4.9; TMPK; dTMPK
EINECS	Contact for details

Quality Control

Our Dtmp Kinase is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, specific activity, and consistency. Certificates of Analysis (COA) detailing parameters such as purity, activity units, and impurity profiles are available upon request. We adhere to relevant quality standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent moisture absorption. For short-term use, aliquoting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (Activity)	Conforms
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content	By Bradford or UV method
Endotoxin Level	< 1.0 EU/μg (if applicable)
Storage Buffer	Tris-HCl, Glycerol, DTT (typical)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.