Description

Adenylyl Cyclase is a critical membrane-bound enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP), a universal secondary messenger. This enzymatic activity is fundamental to numerous intracellular signal transduction pathways, regulating cellular responses to hormones and neurotransmitters. It is an essential reagent for biochemical research, pharmaceutical development, and diagnostic applications, particularly in studies of G-protein-coupled receptor (GPCR) function and cellular metabolism.

Application

• Biochemical Research: A key tool for studying cAMP-mediated signal transduction pathways, enzyme kinetics, and second messenger systems.
• Pharmaceutical Screening: Used in high-throughput screening (HTS) assays to identify and characterize novel drug candidates targeting GPCRs and adenylate cyclase activity.
• Diagnostic Kit Development: Serves as a core component in diagnostic assays for hormonal disorders and diseases related to cellular signaling dysregulation.
• Enzymology Studies: Employed to investigate enzyme mechanisms, inhibition, and activation by forskolin or G-proteins.
• Cell Biology & Physiology: Essential for research into cellular processes like metabolism, gene expression, and ion channel regulation influenced by cAMP levels.
• Academic & Industrial R&D: Supports fundamental and applied research in universities, contract research organizations (CROs), and biotech companies.

Basic Information

Product Name	Adenylyl Cyclase
CAS No.	9012-42-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Adenylate Cyclase; Adenyl Cyclase; ATP Pyrophosphate-Lyase (Cyclizing); 3',5'-Cyclic AMP Synthetase; Adenylyl Cyclase (Membrane-Bound); EC 4.6.1.1
EINECS	Contact for details

Quality Control

Our Adenylyl Cyclase is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high enzymatic activity. Each lot is characterized for specific activity, purity, and stability. A comprehensive Certificate of Analysis (COA), detailing specifications such as activity (units/mg protein), protein concentration, and buffer composition, is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to prevent moisture uptake, which can affect enzymatic activity. Aliquot as received to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Specific Activity	≥ [Value] units/mg protein
Protein Content	Determined by Bradford or similar method
Purity (SDS-PAGE)	≥ 90%
Buffer Composition	Tris-HCl, Glycerol, DTT (typical)
Stability	Retains ≥ 90% activity after 12 months at -20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.