Description

Factor Xa is a serine protease enzyme that plays a critical role in the blood coagulation cascade, serving as the primary activator of prothrombin to thrombin. This makes it a key target for the development of anticoagulant therapeutics and diagnostic assays. It is essential for research and development in the pharmaceutical, biotechnology, and clinical diagnostics industries, particularly for studying thrombosis, hemostasis, and for screening potential antithrombotic drugs.

Application

• Anticoagulant Drug Development: Primary target enzyme for screening and evaluating novel direct oral anticoagulants (DOACs) and other antithrombotic agents.
• Clinical Diagnostics: Used in chromogenic and clotting assays to measure plasma antithrombin activity, heparin levels, and lupus anticoagulants.
• Biochemical Research: Essential tool for studying the kinetics and mechanisms of the coagulation cascade, enzyme inhibition, and structure-activity relationships.
• Pharmaceutical Quality Control: Employed in potency testing and lot release of heparin-based products and other anticoagulant pharmaceuticals.
• In Vitro Diagnostics (IVD) Manufacturing: A critical component in the production of reagent kits for coagulation analyzers used in hospitals and laboratories.

Basic Information

Product Name	Factor Xa
CAS No.	9002-05-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Activated Factor X; Coagulation Factor Xa; Stuart-Prower Factor (Activated); Thrombokinase; EC 3.4.21.6; FXa; Activated Blood Coagulation Factor X
EINECS	Contact for details

Quality Control

Our Factor Xa is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analysis to ensure high specific activity, purity, and functional consistency. Certificates of Analysis (COA) detailing assay results, purity by SDS-PAGE, and absence of contaminating proteases are provided. We adhere to relevant guidelines for biological materials to support your research and manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C or below to prevent loss of activity. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Conforms
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 95%
Protein Content (Biuret)	Contact for details
Solubility	Clear, colorless solution in specified buffer
pH (in solution)	7.0 - 8.0
Endotoxin (LAL)	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.