Description

N(1)-(5-Phosphoribosyl)-5,6-Dimethylbenzimidazole is a key biochemical intermediate and a structural analog of nucleotide derivatives. This compound matters for its critical role in the biosynthesis and study of complex coenzymes, particularly vitamin B12 and related cobalamin derivatives. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity intermediates for synthesis, metabolic pathway research, and enzymatic studies.

Application

• Pharmaceutical Intermediate: Used in the synthesis of vitamin B12 (cobalamin) analogs and other nucleoside-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a crucial precursor or reference standard in studies of enzyme cofactors, nucleotide metabolism, and one-carbon unit transfer pathways.
• Enzymology Studies: Employed as a substrate or inhibitor in enzymatic assays to investigate the function of phosphoribosyltransferases and related enzymes.
• Fine Chemical Synthesis: Acts as a specialized building block for the preparation of modified nucleosides, nucleotides, and labeled compounds for diagnostic applications.
• Microbial Fermentation Research: Utilized in studies and media optimization for microorganisms that produce cobalamin, aiding in yield improvement and metabolic engineering.

Basic Information

Product Name	N(1)-(5-Phosphoribosyl)-5,6-Dimethylbenzimidazole
CAS No.	975-91-7
Molecular Formula	C14H18N3O7P
Molecular Weight	371.28 g/mol
Synonyms	5,6-Dimethylbenzimidazole ribonucleotide; α-Ribazole 5'-phosphate; DMB-riboside 5'-phosphate; 5,6-Dimethyl-1-(5-O-phosphono-β-D-ribofuranosyl)benzimidazole; 1-(5-Phospho-α-D-ribosyl)-5,6-dimethylbenzimidazole; N1-(5-Phosphoribosyl)-5,6-dimethylbenzimidazole; α-Ribazole phosphate
EINECS	Contact for details

Quality Control

Our N(1)-(5-Phosphoribosyl)-5,6-Dimethylbenzimidazole is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets high-purity standards suitable for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your application requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.