Description

5-Fluoro-1-[(2R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidine-2,4-Dione is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer agents, where its specific stereochemistry and fluorine substitution are essential for biological activity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated nucleoside analogs and prodrugs for antiviral and anticancer applications.
• Antiviral Drug Research: Used in the development of novel compounds targeting viral polymerases and reverse transcriptases.
• Oncology Research: Serves as a scaffold for creating chemotherapeutic agents that interfere with DNA synthesis and repair in cancer cells.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial production of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Product Name	5-Fluoro-1-[(2R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidine-2,4-Dione
CAS No.	955-24-8
Molecular Formula	C9H11FN2O6
Molecular Weight	262.19 g/mol
Synonyms	5-Fluoro-2'-deoxyuridine; 5-Fluoro-2'-deoxyuridine (FdUrd); 5-Fluoro-2'-deoxyuridine; Floxuridine impurity; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-fluorouracil; 5-Fluoro-1-(2-deoxy-β-D-ribofuranosyl)uracil; 5-Fluoro-2'-deoxyuridine (5-FdU); NSC 27640
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1-[(2R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidine-2,4-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and stringent control of impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.